San Francisco

Great, there go my insurance rates again.

San Francisco, California, seems to be a multiversal sufferer of Transformers-related abuse. It has been targeted for nukes at least twice. Once successfully, and another time it was "only" contaminated by nuclear fall-out.

And yet the rent is so high. I don't understand. Makes you long for the days when it was only being savaged by weird robot bird-dragons that hatched out of asteroids or angry gestalts.

Fiction

Generation 2 continuity

Jhiaxus of the Cybertronian Empire fired upon San Francisco with an energy weapon of some sort, vaporizing the city to a radius of several miles - simply as an "up yours" gesture to Optimus Prime.

The tourist trade never recovered.

Dreamwave continuity

As part of his plan to eradicate Earth and to emphasise to Optimus that humans weren't fighting for, Megatron launched a massed assault on San Francisco. (Why do comic-book Decepticon leaders target this specific city when they want to get at Prime?) Devastator tore through the city before the Autobots arrived to stop Megatron, but the damage was still extensive.

Then General Hallo decided to fire a nuclear missile at the city to wipe out all the Transformers - while stopped, the shockwave from the blast still hit the city. Ouch.

Keepers Trilogy

Forthcoming.

IDW Hearts of Steel continuity

Forthcoming.

From Teletraan I: The Transformers Wiki, a Wikia wiki.