San Francisco
San Francisco, California is a beautiful city; cable cars, fog rolling off the bay, Chinatown, the Golden Gate Bridge, the wharf. Gee, I wish I lived there, NOT. Actually it seems to be a multiversal sufferer of Transformers-related abuse. It has been targeted for nukes at least twice—once it was hit successfully, and another time it was "only" contaminated by nuclear fallout.
And yet the rent is so high. We don't understand. Makes you long for the days when it was only being savaged by weird robot bird-dragons that hatched out of asteroids or angry gestalts.
Fiction
Generation 1 cartoon continuity
The Transformers cartoon
When an asteroid bird alien was accidentally hatched in a battle between the Constructicons and Omega Supreme, it got hungry and flew down to San Francisco to feed. It gnawed on the tip of the Transamerica Pyramid and caused general mayhem in the city before it was lured back into space by Omega Supreme. The Secret of Omega Supreme
The Headmasters cartoon
Scorponok planted a giant alien carnivorous plant in San Francisco. The local authorities and an Autobot rescue force proved incapable of stopping its rampage until Fortress Maximus arrived and sliced it up. Head On!! Fortress Maximus
Marvel Comics continuity
Generation 1 comic
Clifford Dietz, a friend of Spike Witwicky, lived in San Francisco. The Man in the Machine!
Generation 2
Jhiaxus of the Cybertronian Empire fired upon San Francisco with an energy weapon of some sort, vaporizing the city to a radius of several miles—simply as an "up yours" gesture to Optimus Prime. Dark Shadows!
Dreamwave comics continuity
As part of his plan to eradicate Earth and to emphasise to Optimus Prime that humans weren't worth fighting for, Megatron launched a massed assault on San Francisco. (Why do comic-book Decepticon leaders target this specific city when they want to get at Prime? Maybe the Autobot leader spends his summers there.) Devastator tore through the city before the Autobots arrived to stop Megatron, but the damage was still extensive.
Then General Hallo decided to fire a nuclear missile at the city to wipe out all the Transformers, forcing Superion to sacrifice his life to save everyone else. While the actual missile strike was stopped, the shock wave from the blast still hit the city. Ouch. Prime Directive
Keepers Trilogy
As it turns out, San Francisco was contaminated with radiation from the fallout.
IDW Hearts of Steel continuity
Stanford Merriweather and his daughter Kitty lived in San Francisco in the late 19th century. Their house was destroyed in a battle between Ravage and Mark Twain. Thankfully, that seems to be the only damage the city suffered. Hearts of Steel #3
IDW comics continuity
The Decepticons attacked San Francisco. We didn't see it and nobody seemed bothered, probably figuring "well of course they have". All Hail Megatron #3
Live-action movie continuity
IDW Transformers movie comics
The Decepticons Dead End and Swindle landed in San Francisco, where Swindle blew some crap up to distract the Autobots—geez, now the city isn't even a main target. Alliance #3
