Nuclear weapon
Nuclear weapons, also known as atom bombs or nukes, are extremely powerful weapons that harness atomic energy.
Fiction
Marvel Comics continuity
Marvel The Transformers comics
As G.B. Blackrock was preparing to unveil his new his new weapon to deal with the giant robots in the area at the Blackrock Motor Speedway, a journalist asked him if it was true that the weapon fired nuclear missiles. DIS-Integrated Circuits!
During his time in control of the Ark, Shockwave reprogrammed the combat drone Guardian and booby-trapped it with a thermo-nuclear bomb. The Wrath of Guardian! With the bomb's countdown timer ticking, Swoop carried Guardian away from the Ark, saving the Autobot base from the explosion but seemingly at the cost of his own life. The Wrath of Grimlock!
Rhythms of Darkness!
With the North American continent under the control of Galvatron, the governments of the Earth's remaining free nations planned to eliminate the Decepticon threat with a nuclear strike. However, thanks to the efforts of Spike, Lisa, and a handful of Autobots, the US flag was raised above the Decepticon Powerbase as a sign that America was still fighting and the strike was called off. Rhythms of Darkness!
Regeneration One
Dreamwave Generation One continuity
As the Autobots and Decepticons fought in San Francisco, General Hallo decided to fire a nuclear missile at the city to wipe out all the Transformers, Prime Directive #5 forcing Superion to sacrifice his life to save everyone else. While the actual missile strike was stopped, the shock wave from the blast still hit the city. Prime Directive #6 San Francisco was contaminated with radiation from the fallout. Hardwired
G.I. Joe vs. the Transformers
Wheeljack and Bumblebee intended to partner with G.I. Joe in an attack on Cobra Island to rescue the captured and brainwashed Autobots, but the humans' higher-ups disagreed, planning to nuke the island instead. Hawk regretfully incapacitated the robots with a magnetic pulse, but Wheeljack stayed conscious enough to overhear their plans and warned Hawk that a nuclear impact on Cobra's energon stockpile would cause a chain reaction and send half the planet into a nuclear winter. With this revelation, Hawk broke orders and went ahead with the original strategy. G.I. Joe vs. the Transformers #4
Upon arriving at the island, Wheeljack patched through a message to all Autobots that the United States had decided to nuke Cobra Island despite having their own troops located there. G.I. Joe vs. the Transformers #5 He quickly improvised a way to avoid the impending nuclear holocaust by using the SPS Satellite's solar-powered energy beams to shoot down the nuclear warheads before they arrived. G.I. Joe vs. the Transformers #6
2005 IDW continuity
With Megatron and his Decepticons squabbling over control of New York City, the European Union launched a nuclear strike against them. All Hail Megatron #10 However, the plane carrying the nuclear bomb turned out to be Tankor in disguise. All Hail Megatron #11 Megatron ordered Tankor to drop the bomb anyway, but it was ultimately intercepted and diverted into space by Thundercracker. All Hail Megatron #12
Thundercracker's movie Last Laugh: The Life and Death of Chuckles depicted the title character saving the entire world from Cobra Commander's fiendish plot to launch nuclear missiles. Starscream: The Movie
The Cobra terrorist Cesspool, assisted by his mutant Army Ants, held Mexico City to ransom with a nuclear bomb. As G.I. Joe arrived to shut his plot down, Cesspool threatened to detonate his bomb but was taken out by Lady Jaye with a laser javelin to the back. Scarlett's Strike Force #1
Ask Vector Prime
With the success of the Autobots' S.T.A.R.S. program, the Decepticons of Primax 185.0 Beta responded with their own Decepto-Packs, enslaving humans to augment their capabilities and help them conquer the planet. Galvatron eventually provoked a nuclear strike that provided him the energon necessary to have his slaves build Zod drones, which he unleashed across the universe, conquering many systems. Ask Vector Prime, 2015/06/04
Bumblebee Movie Prequel
The Decepticon Malignus sought to inflame the Cold War into open conflict, intending to use the cover of a nuclear war to allow the Decepticons to move about undetected. As he prepared to launch a nuclear missile from an abandoned castle on a peninsula of the United Kingdom at the Soviet Union, his plans were foiled by the interventions of Bumblebee, David Reeve, Diana Lux, and ultimately, Diabla. From Cybertron with Love
2019 IDW continuity
The Thraal carried out a policy of deliberate, targeted sterilization of the A'ovan homeworld by bombarding the planet with nuclear weapons. Nautica: Home Though a small population of A'ovan refugees were able to find sanctuary on Cybertron, their planet was left an irradiated wasteland. The World In Your Eyes Part Two
